一、基本信息
王金辉,药物化学博士,대왕카지노 사이트天然药物化学教授,博士生导师,入选教育部“新世纪优秀人才支持计划”、“辽宁省百人计划”等。主要致力于中药和天然药物中药效成分的研究与开发、中药有效成分代谢和动力学研究、中药炮制及饮片质量规范化研究、中药创新药物的研究与开发、基于基因组学、代谢组学的中药复方配伍机制研究;作为首席科学家主持国家科技支撑计划项目1项、国家科技重大专项重大新药创制、国家863课题1项,国家自然科学基金等项目;获得发明专利10多项;2006年以来,SCI收录论文100余篇, EI收录论文8篇,专著4部;获新疆生产建设兵团科技进步一等奖1项、黑龙江省科技进步二等奖1项、新疆自治区科技进步二等奖1项,获新疆生产建设兵团青年科技奖、辽宁省青年科技奖。
二、主持科学研究项目
1. 国家重大科技专项《中药民族药组分资源库建设》。
2. 国家科技支撑计划项目《维吾尔、哈萨克药生物活性成分筛选和现代标准组分库建设》。
3. 国家自然科学基金《圆根大戟和甘遂中保护多巴胺所致SH-SY5Y 细胞损伤帕金森模型作用和机制研究》。
4. 国家自然科学基金《新疆荒漠植物多伞阿魏中彗星状化合物对神经胶质瘤C6细胞的抗肿瘤作用及其机制研究》。
5. 国家863项目《阿魏侧耳免疫调节多糖制备技术及其口含给药系统的研究》(2008AA10Z323)。
6. 国家自然科学基金《新疆鼠尾草属植物改善心肌缺血有效成分-丹参酚酸A及其构效关系研究》。
7. 石河子大学自然科学重点项目《新疆酚酸类药用植物调控黏附分子ICAM-1表达及其质量控制研究》。
三、讲授课程
1. 硕士研究生:波谱解析
2. 本科生课程:天然药物化学、波谱解析、药学英语、药学概论
四、代表性成果(从近到远……)
1. 代表论文
[1] Dahong Yao#, Chenyang Li#, Muhammad Shahid Riaz Rajoka, Zhendan He, Jian Huang, Jinhui Wang*, Jin Zhang*. P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in cancer. Theranostics, 2020, 10(21):9741-9766.
[2] Dahong Yao, Dabo Pan, Yongqi Zhen, Jian Huangd, Jinhui Wang**, Jin Zhang*, Zhendan He*. Ferulin C triggers potent PAK1 and p21-mediated anti-tumor effects in breast cancer by inhibiting Tubulin polymerization in vitro and in vivo. Pharmacological Research, 2020, 152: 104605-104618.
[3] Hong-feng Zhang, Jia-hong Wang, Yan-li Wang, Cheng Gao, Yan-ting Gu, Jian Huang, Jin-hui Wang*, Zhou Zhang*. Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats. Oxidative Medicine and Cellular Longevity, 2019, 2019:2853534-2853550.
[4] Xiaobin Xin, Dahong Yao, Ke Zhang*, Shuai Han, Danni Liu, Hangyu Wang, Xueying Liu, Guoyu Li, Jian Huang, Jinhui Wang*. Protective effffects of Rosavin on bleomycin-induced pulmonary fifibrosis via suppressing fifibrotic and inflflammatory signaling pathways in mice. Biomedicine & Pharmacotherapy, 2019, 115:108870-108877.
[5] Shu-Yun Wang, Chao Huang, Ren-Kuan Sun, Li-Na Lu, Hong-Gang Liang, Le Gao, Jian Huang*, Jin-Hui Wang*, Bao-Feng Yang. New tirucallane triterpenoids from the dried latex of Euphorbia resinifera. Phytochemistry Letters, 2019, 29:220-224.
[6] Jiao Jiayuan, Wu, Jiming, Wang Jiali, Guo Yaping, Gao Le, Liang Honggang, Huang Jian*, Wang Jinhui*. Ma Huang Tang ameliorates bronchial asthma symptoms through the TLR9 pathway. Pharmaceutical Biology, 2018, 56: 580-593.
[7] Yiting Wang, Yanmei Chen, Xiaoling Cheng, Ke Zhang, Hangyu Wang*, Bo Liu*, Jinhui Wang*. Design, synthesis and biological evaluation of pyrimidine derivatives as novel CDK2 inhibitors that induce apoptosis and cell cycle arrest in breast cancer cells. Bioorganic & Medicinal Chemistry, 2018, 26: 3491-3501
[8] Jin Lu, Lei Shang, HuiminWen, Jian Huang*, Guoyu Li, Jinhui Wang*. Structural identification and biological activity of six new Shellolic esters from Lac. Fitoterapia, 2018, 125: 221-226
[9] Wang Zhen-Hui, Huang Jian, Niu Chao, Wang Jin-Hui*, Wu Bin*. Isopimarane-type diterpenoids from Callicarpa macrophylla vahl. Phytochemistry, 2017, 22: 224-228
[10] Lu Yang, Guo Yu Li, Hang Yu Wang, Ke Zhang, Yun Zhu, Wenbin Zhao, Heng Wang, Jin Hui Wang*, Five new N-acetyldopamine dimers from Periostracum Cicadae. Phytochemistry Letters. 2016, 16: 97-102
[11] Ke Zhang, Xiao-ping Si, Jian Huang*, Jian Han, Xu Liang, Xiaobo Xu, Guo-yu Li, Yi-ting Wang, Hang-yu Wang, Jin-hui Wang*. Preventive effects of Rhodiola rosea L. on bleomycin-induced pulmonary fibrosis in rats. International journal of Molecular Sciences. 2016, 17: 879-900
[12] Huang Jian, Zheng Yaxin, Wu Wenxi, Xie Tao, Yao Hong, Pang Xiaobo, Sun Fuzhou, Ouyang Liang, Wang Jinhui*. CEMTDD: The database for elucidating the relationships among herbs, compounds, targets and related diseases for Chinese ethnic minority traditional drugs. Oncotarget. 2015, 6: 17675-17684
2. 发明专利
[1] 王金辉,黄健,孙富周. 白僵蚕抗肿瘤提取物及其组合物的制备方法和医药用途[P]. 中国:CN201510080664.8, 2019-08-30
[2] 王金辉,李国玉,黄健,高红英,杜小威,韩英,王书云,安丽娟,王立飞,程锁明,孙富周. 竹叶青酒中的生物活性成分及其医药用途[P]. 中国:ZL201510314424.X, 2018-06-05
[3] 王金辉,热娜·卡斯木,李国玉,黄健,姚大红,胡君萍,马庆东,张珂,陈雪珊. 多刺绿绒蒿α-糖苷酶抑制活性提取物及其组合物的医药用途和制备方法[P]. 中国:CN201510058737.3, 2018-04-20
[4] 田丽萍,王金辉,薛琳,张义晖,湛圆圆,李欠南,张彬,李守明. 打瓜皮提取物及其组合物的医药用途和制备方法[P]. 中国:CN201410752165.4, 2017-04-19
[5] 王金辉,曾毅梅,李国玉. 一组中药芫花二萜原酸酯类化合物[P]. 中国:CN200910176448.8, 2012-01-25
[6] 王金辉,李国玉,巩平,魏秀岩,黄健,王莹,杨琳,卢丽娜,秦颖,张萃,阿魏侧耳多糖及其组合物的医药用途和制备方法[P]. 中国:CN201010272986.X, 2010-09-06.
五、联系方式
1. E-mail:15999290001@163.com
2. 通讯地址:新疆维吾尔自治区石河子市,北2路59号,石河子大学医学校区,대왕카지노 사이트
3. 邮编:832002
六、学生及实验室照